Tucatinib
Catalogue number:
CAY31411-25 mg
Supplier:
Size:
25 mg
Product is available in:
£236.00
Estimated delivery Fri 3 Jul
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
937263-43-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H24N8O2
Molecular Weight:
480.52148
Alternative Names:
n6-(4,5-di
Product Description:
An inhibitor of HER2 (IC50 = 14 nM); inhibits the phosphorylation of HER2 in BT474 breast carcinoma cells (IC50 = 21 nM); inhibits phosphorylation of AKT and induces apoptosis in BT474 cells; inhibits tumor growth in NCI N87 gastric carcinoma and SKOV3 ovarian adenocarcinoma mouse xenograft models from 25-100 mg/kg; reduces intratumor phosphorylation of AKT and ERK and inhibits tumor growth in a BT474 mouse xenograft model