PF-06424439
Catalogue number:
CAY17680-25 mg
Supplier:
Size:
25 mg
Product is available in:
£448.00
Estimated delivery Mon 20 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1469284-79-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H26ClN7O • CH3SO3H
Molecular Weight:
536
Alternative Names:
[(3r)-1-[2-
Product Description:
An orally bioavailable inhibitor of DGAT-2 (IC50 = 14 nM); selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 µM); reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner from 0.1-10 mg/kg; reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet at 60 mg/kg per day