Isoguvacine (hydrochloride)
Catalogue number:
CAY33143-50 mg
Supplier:
Size:
50 mg
Product is available in:
£184.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
68547-97-7
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C6H9NO2 • HCl
Molecular Weight:
163.60184
Alternative Names:
1,2,3,6-tetra
Product Description:
A GABAA; binds to rat synaptic cortical membranes (Ki = 55 nM); activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively); inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM); inhibits potassium/low magnesium-induced seizures in rat pups; chronic administration improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of ASD at 2 mg/kg