Imidazole Ketone Erastin
Catalogue number:
CAY27088-1 mg
Supplier:
Size:
1 mg
Product is available in:
£133.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1801530-11-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C35H35ClN6O5
Molecular Weight:
655.1
Alternative Names:
2-[[4-[2-(4-
Product Description:
An inducer of ferroptosis; inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter; increases production of lipid ROS in SUDHL6 DLBCL cells in a concentration-dependent manner, as well as reduces GSH levels in these cells (IC50 = 34 nM); inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM); reduces tumor growth in an SUDHL6 mouse xenograft model at 23 and 40 mg/kg