Nicergoline
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27848-84-6
≥98%
A solid
C24H26BrN3O3
484.38566
(8β)-10-methoxy-1,6-dimethyl-ergoline-8-methanol, 8-(5-bromo-3-pyridinecarboxylate), fi-6714, nicotergoline, nsc 150531, ta-079
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- MSDS: View or download
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 µg/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury