Alofanib
Catalogue number:
CAY31754-100 mg
Supplier:
Size:
100 mg
Product is available in:
£819.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1612888-66-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C19H15N3O6S
Molecular Weight:
413.40502
Alternative Names:
3-[[[4-methyl-
Product Description:
An allosteric inhibitor of FGFR2; inhibits FGF2-induced phosphorylation of FRS2α in KATO III cells (IC50 = 10 nM); inhibits the growth of SKOV3 and Hs 578T cells (GI50s = 370 and 210 nM, respectively); inhibits bFGF-induced HUVEC proliferation (IC50 = 11 nM); inhibits SVEC4-10 cell tube formation at 50 nM; decreases the number of tumor microvessels by 50% in a SKOV3 ovarian serous carcinoma mouse model; reduces tumor growth in mouse xenograft models at 30 mg/kg per day