CAIX Inhibitor S4
Catalogue number:
CAY31119-25 mg
Supplier:
Size:
25 mg
Product is available in:
£425.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1330061-67-0
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C15H17N3O4S
Molecular Weight:
335.3793
Alternative Names:
sulfamic acid, 4-[[[(3,5-
Product Description:
A CAIX inhibitor (Ki = 0.007 µM for the recombinant human enzyme); selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6, 0.55, and 0.002 µM, respectively); inhibits proliferation of HT-29 and MDA-MB-231, but not HCT116, cancer cells under anoxic conditions (IC50s = 20, 481, and >1,000 µM, respectively); reduces the number of lung metastases, but not primary tumor growth, in an MDA-MB-231 mouse xenograft model at 10 mg/kg