Takinib
Catalogue number:
CAY24161-1 mg
Supplier:
Size:
1 mg
Product is available in:
£46.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1111556-37-6
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C18H18N4O2
Molecular Weight:
322.4
Alternative Names:
n1-(1-propyl-
Product Description:
A TAK1 inhibitor (IC50 = 9.5 nM); selective for TAK1 over IRAK1, IRAK4, GCK, Clk2, and MINK1 (IC50s = 390, 120, 430, 430, and 1,900 nM, respectively); increases caspase-3/-7 activity and inhibits proliferation of TNF-α-stimulated, but not unstimulated, MDA-MB-231 cells; reduces phosphorylation of IKK, p38 MAPK, MAPK8, MAPK9, and c-Jun in TNF-α-stimulated MDA-MB-231 cells; inhibits IL-6 secretion in TNF-α-stimulated rheumatoid arthritis fibroblast-like synoviocytes; reduces inflammation and cartilage damage in knee joints in a mouse model of collagen type II-induced arthritis at 50 mg/kg per day