ARV-771
Catalogue number:
CAY21299-1 mg
Supplier:
Size:
1 mg
Product is available in:
£80.00
Estimated delivery Fri 15 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1949837-12-0
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C49H60ClN9O7S2
Molecular Weight:
986.6
Alternative Names:
(2s,4r)-1-((s)-
Product Description:
A PROTAC that drives BET family protein degradation; induces degradation of BRD2, BRD3, and BRD4 in 22Rv1 CRPC cells (DC50s = <5 nM for all); inhibits proliferation of and increases PARP cleavage in 22Rv1 cells in a concentration-dependent manner; reduces full-length androgen receptor protein levels and prevents R1881-induced increases in ERG in VCaP cells; induces tumor regression in a 22Rv1 mouse xenograft model at 30 mg/kg per day, s.c.