ABP 688
Catalogue number:
CAY30929-500 ug
Supplier:
Size:
500 µg
Product is available in:
£46.00
Estimated delivery Wed 24 Jun
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
924298-51-1
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C15H16N2O
Molecular Weight:
240.30042
Alternative Names:
3-[2-(6-methyl-
Product Description:
A non-competitive antagonist of mGluR5 (Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors); binds at an allosteric binding site; selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 µM; inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively); radiolabeled forms have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents