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53026-37-2
≥70%
A solid
C48H82O18
947.15388
(29s)-9,13:17,20:21,24-trianhydro-4,8,10,12,14,18,19,22,23,26,28,30-dodecadeoxy-4,12,14,26,28-pentamethyl-6,16-di-c-methyl-5,6,11,15-tetra-o-methyl-27-o-[(2r,5s,6r)-tetrahydro-5-methoxy-6-methyl-2h-pyran-2-yl]-l-xylo-l-manno-α-d-gluco-l-ribo-α-l-gluco-d-g
A fungal metabolite with antibiotic and antiparasitic activities; active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively); active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively); has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively)