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12-keto Lithocholic Acid

Catalogue number:
CAY29547-25 mg
Supplier:
Size:
25 mg
Product is available in:
  • UK
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£299.00 Estimated delivery Thu 26 Mar
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

5130-29-0

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C24H38O4

Molecular Weight:

390.6

Alternative Names:

(3α,5β)-3-hydroxy-12-oxo-cholan-24-oic acid, 12-keto lca, 12-keto lithocholate, 12-klca, 12-oxo lca, 12-oxo lithocholate, 12-oxo lithocholic acid

Product Description:

A metabolite of DCA; fecal levels are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol, HDCA, or LCA; activates the human PXR (EC50 = 31.3 µM in a cell-based transactivation assay); levels are increased in duodenal bile from patients with type 2 diabetes