Dehydrolithocholic Acid
Catalogue number:
CAY29544-250 mg
Supplier:
Size:
250 mg
Product is available in:
£338.00
Estimated delivery Wed 24 Dec
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1553-56-6
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C24H38O3
Molecular Weight:
374.55672
Alternative Names:
(5β)-3-oxo-
Product Description:
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 µM), VDR (EC50 = 3 µM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 µM) and activates mouse and human PXRs in cell-based reporter assays at 100 µM; binds to RORγt (Kd = 1.13 µM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 µM; inhibits the differentiation of TH17 cells at 20 µM