Gene editing tools for drug discovery

Drive efficient & accurate genome editing with high-activity enzymes from KACTUS, before confidently assessing editing activity & cellular responses using validated & ready-to-use assay kits from BPS Bioscience.

Why choose BPS Bioscience for your gene editing assay kits?

BPS Bioscience is a trusted provider for gene editing assays, offering deep expertise in CRISPR-Cas9 technology, custom cell line engineering, and end-to-end assay services. BPS offers validated biochemical and cell-based assay kits that utilise high-activity proteins to advance gene editing research, inhibitor screening, and antibody validation. These kits are ready-to-use, customisable, and engineered to deliver consistent, reproducible results.

Benefits of using BPS gene editing assay kits

• Validated & ready-to-use biochemical & cell-based assay kits
• Ideal for high-throughput screening
• Orthogonal testing support available
• Custom assays development options available

Why choose KACTUS for your gene editing enzymes?

KACTUS provide high-activity enzymes for CRISPR, expertly manufactured to both research and GMP-grade standard. Additionally, KACTUS is recognised for pioneering commercial firsts when it comes to gene editing research tools.

Cas9 enzyme
Their CRISPR Cas9 protein is a wild-type nuclease designed to achieve better ribonucleoprotein (RNP) editing efficiency across a range of different cell types, including primary T cells.

AccuBase® base editor enzyme
KACTUS also offer the first commercially available cytosine base editor, AccuBase®. Manufactured under cGMP conditions, this enzyme integrates a deaminase within the Cas protein structure to prevent off-target binding, delivering high editing precision with minimal unintended effects. AccuBase® efficiently converts C-G base pairs to T-A, making it ideal for precise gene correction applications.

Benefits of using KACTUS gene editing enzymes

• High activity & purity for reliable gene editing results
• GMP-grade options available providing long-term stability
• Large-scale production with strict QC for batch consistency
• Custom design options available

Why do BPS biochemical & cell-based assays work so well with KACTUS gene editing enzymes?

Our combination of BPS Bioscience and KACTUS technologies ensures high performance, reproducibility and accelerated discovery throughout the gene editing process. KACTUS provide high-quality CRISPR-associated nucleases for precise and efficient genome manipulation, whereas BPS Bioscience’s range of well-validated assay kits enable researchers to accurately validate, quantify and optimise editing outcomes.

Applications
• CRISPR-Cas9 and gene editing in cell-based assays
• Pathway analysis (signaling, RNAi, knockout) using reporter assays
• PD-1/PD-L1/PD-L2 inhibitor/activator screening (immune checkpoint studies)
• CAR-T cell functional screening for cancer immunotherapy
• High-throughput screening for gene-editing effects in cellular models
• Transient transfection assays with reporter kits for pathway monitoring
• Study of gene overexpression or knockdown effects on signaling
• ADCC (Antibody-Dependent Cellular Cytotoxicity) assays
• Checkpoint molecule inhibitor discovery for immunotherapy
• Customised cell expression kits