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Complement and thromboinflammation assays for SARS-CoV-2 research

Working closely with their collaborators, Hycult Biotech have been examining the role of complement and thromboinflammation in COVID-19 with the aim of identifying the inflammatory processes and validating biomarkers that would be supportive for therapeutic interventions. It is evident that the innate immune system has a pivotal role in relation to the inflammatory storm seen in SARS-CoV-2 infected patients with hyper activation appearing to contribute towards lung damage, whilst microvascular injury of the thromboinflammation pathway has also been observed.

Complement and thromboinflammation assays
Cambridge Bioscience offer a comprehensive range of assays from Hycult Biotech to accurately quantify these complement biomarkers, such as C3,C3c, C5 and TCC, as well as thromboinflammation biomarkers. With wide sample compatibility and exceptional reliability and reproducibility, these assays can assist in the development of potential therapeutic approaches targeting complement and the innate immune system for COVID-19.

Benefits of using the Hycult Biotech assays
• Wide sample compatibility
• Wide standard range
• Low detection level
• Exceptional reliability and reproducibility
• Tested by two independent operators before batch release
• Validated using both diseased and healthy samples together with an external reference centre

Complement Thromboinflammation Lung injury
MBL assays sThrombomodulin assays sMR/sCD206 assays
MASP2 assays Coagulation factor XII assays PTX3 assays
C3 assays gC1qR assays MPO assays
C3a assays uPAR antibodies Elastase assays
C3c assays EPCR antibodies SP-D assays
C5 assays APC antibodies  
C5a assays    
TCC assays    
Factor H assays    
Mouse C5 blocking antibodies    
Mouse C5aR blocking antibodies    

Validated assay sample types: Bronchoalveolar fluid, cell culture supernatant, cerebrospinal fluid, joint fluid, plasma, serum, sputum and urine.

Products

Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
MBL, Human, ELISA kit HK323-02 · Hycult Biotech
HK323-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
MASP-2, Human, ELISA kit HK326-02 · Hycult Biotech
HK326-02
Hycult Biotech
2 x 96 detections £1083.00
2 x 96 detections
view
C3, Human, ELISA kit HK366-02 · Hycult Biotech
HK366-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
C3a, Human, ELISA kit HK354-02 · Hycult Biotech
HK354-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
C3c, Human, ELISA kit HK368-02 · Hycult Biotech
HK368-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
C5, Human, ELISA kit HK390-02 · Hycult Biotech
HK390-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
C5a, Human, ELISA kit HK349-02 · Hycult Biotech
HK349-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
TCC, Human, ELISA kit HK328-02 · Hycult Biotech
HK328-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
Complement factor H, Human, ELISA kit HK342-02 · Hycult Biotech
HK342-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
C5, Mouse, mAb BB5.1 HM1073-1MG · Hycult Biotech
HM1073-1MG
Hycult Biotech
1 mg £1257.00
1 mg
view
C5aR, Mouse, mAb 20/70 HM1076-100UG · Hycult Biotech
HM1076-100UG
Hycult Biotech
100 µg £464.00
100 µg
view
sThrombomodulin, Human, ELISA kit HK383-02 · Hycult Biotech
HK383-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
Coagulation factor XII, Human, ELISA kit HK373-02 · Hycult Biotech
HK373-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
gC1qR, Human, ELISA kit HK362-02 · Hycult Biotech
HK362-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
uPAR (D2 domain), Human, mAb IIIB11 HM2143-100UG · Hycult Biotech
HM2143-100UG
Hycult Biotech
100 µg £310.00
100 µg
view
EPCR, Human, mAb RCR-252 HM2145-100UG · Hycult Biotech
HM2145-100UG
Hycult Biotech
100 µg £464.00
100 µg
view
Protein C, Human, mAb PC107 HM2151-100UG · Hycult Biotech
HM2151-100UG
Hycult Biotech
100 µg £310.00
100 µg
view
Soluble mannose receptor, Human, ELISA kit HK381-02 · Hycult Biotech
HK381-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
Pentraxin 3, Human, ELISA kit HK347-02 · Hycult Biotech
HK347-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
MPO, Human, ELISA kit HK324-02 · Hycult Biotech
HK324-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
Elastase, Human, ELISA kit HK319-02 · Hycult Biotech
HK319-02
Hycult Biotech
2 x 96 detections £918.00
2 x 96 detections
view
Alpha-1-antitrypsin, Human, ELISA kit HK387-02 · Hycult Biotech
HK387-02
Hycult Biotech
2 x 96 detections £1083.00
2 x 96 detections
view
Proteinase 3, Human, ELISA kit HK384-02 · Hycult Biotech
HK384-02
Hycult Biotech
2 x 96 detections £1021.00
2 x 96 detections
view
SP-D, Human, ELISA kit HK335-02 · Hycult Biotech
HK335-02
Hycult Biotech
2 x 96 detections £846.00
2 x 96 detections
view