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In vivo antibodies: InVivoMAb and InVivoPlus

InVivoMAb™ and InVivoPlus™ antibodies from Bio X Cell are trusted, high-performance monoclonal antibodies for in vivo research. Also suitable for in vitro use, these ultra-pure, low endotoxin antibodies are free from preservatives, stabilisers and carrier proteins - making them ideal for use in preclinical studies such as immunotherapy research, tumour models and autoimmune disease investigations.

The InVivoMAb product line includes a wide selection of research-grade in vivo antibodies, such as the well-cited anti-PD-1 clone RMP1-14 and anti-PD-L1 clone 10F.9G2, commonly used to investigate immune checkpoint inhibition and boost T cell responses in cancer models. These carrier-free antibodies for tumour models are specifically formulated for use in mouse models and other in vivo systems requiring high purity and reproducibility.

For studies with heightened quality demands, InVivoPlus antibodies undergo additional testing, including endotoxin screening, aggregation analysis and murine pathogen detection. With proven batch-to-batch consistency and rigorous QC, InVivoPlus are the ideal choice for sensitive in vivo experiments.

Benefits of using InVivoMAb and InVivoPlus

  • Monoclonal antibodies for in vivo research
  • >95% purity
  • Ultra-low endotoxin antibodies
  • Free of preservatives, stabilisers & carrier proteins
  • Block, neutralise, activate or deplete targets
  • PD-1 & CTLA-4 in vivo antibodies available
  • Ideal for preclinical studies, including immunotherapy research, tumour medals & autoimmune disease investigation
  • Cited in over 20,000 publications


Differences between InVivoMAb and InVivoPlus

Tested for: InVivoMAb InVivoPlus
Binding validation
By ELISA, flow cytometry or immunoblot
No Yes
Screening for murine pathogens
By ultra-sensitive real-time PCR
No Yes
Screening for antibody aggregation
By size exclusion chromatography
No Yes
Endotoxin
By LAL gel clotting assay
<2EU/mg <1EU/mg
Purity
By SDS-PAGE
>95% >95%
Preservative/stabiliser/carrier protein-free Yes Yes
Formulated for in vivo use Yes Yes
Catalogue number format Begins with BE Begins with BP


Applications
Cancer immunotherapy
Tumour immunology
Immune checkpoint blocking 
Mouse cell specific depletion
Cytokine neutralisation 
Agonistic/cell activation 
Receptor blocking
In vivo CD4+ T cell depletion

Downloadable materials
Bio X Cell cancer brochure
Bio X Cell depletion antibodies brochure
Bio X Cell immunology brochure

in vivo mab,in vivo plus,in vivo antibody,in vivo ab

Products

Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
InVivoPlus polyclonal Armenian hamster IgG BP0091-R005mg · Bio X Cell
BP0091-R005mg
Bio X Cell
5 mg £690.00
5 mg
view
InVivoMAb polyclonal rabbit IgG BE0095-R005mg · Bio X Cell
BE0095-R005mg
Bio X Cell
5 mg £530.00
5 mg
view
InVivoMAb anti-mouse MAdCAM-1 BE0035-R001mg · Bio X Cell
BE0035-R001mg
Bio X Cell
1 mg £145.00
1 mg
view
InVivoPlus mouse IgG1 isotype control, unknown specificity BP0083-R100mg · Bio X Cell
BP0083-R100mg
Bio X Cell
100 mg £4917.00
100 mg
view
InVivoMAb anti-mouse 4-1BBL (CD137L) BE0110-R005mg · Bio X Cell
BE0110-R005mg
Bio X Cell
5 mg £530.00
5 mg
view
InVivoMAb anti-mouse IL-7Rα (CD127) BE0065-R001mg · Bio X Cell
BE0065-R001mg
Bio X Cell
1 mg £145.00
1 mg
view
InVivoMAb anti-mouse ICOS BE0059-R001mg · Bio X Cell
BE0059-R001mg
Bio X Cell
1 mg £145.00
1 mg
view
InVivoPlus rat IgG1 isotype control, anti-trinitrophenol BP0290-R100mg · Bio X Cell
BP0290-R100mg
Bio X Cell
100 mg £4917.00
100 mg
view
InVivoMAb anti-mouse PD-L1 (B7-H1) BE0101-R005mg · Bio X Cell
BE0101-R005mg
Bio X Cell
5 mg £560.00
5 mg
view
InVivoMAb anti-mouse Thy1 (CD90) BE0076-R001mg · Bio X Cell
BE0076-R001mg
Bio X Cell
1 mg £145.00
1 mg
view
InVivoMAb anti-human CD54 (ICAM-1) BE0020-2-R001mg · Bio X Cell
BE0020-2-R001mg
Bio X Cell
1 mg £145.00
1 mg
view
InVivoMAb mouse IgG2b isotype control, unknown specificity BE0086-R001mg · Bio X Cell
BE0086-R001mg
Bio X Cell
1 mg £145.00
1 mg
view