iPSC models for neurodegenerative disease research

The drug discovery community is urgently seeking more human-relevant, scalable, and accessible model systems beyond traditional in vitro and in vivo methods. AXOL Bioscience addresses this issue by offering their axoCells iPSC-derived cells designed to aid in compound screening, toxicity studies, and basic research, for a wide variety of diseases.

Part of the range focuses on iPSC-derived cells specifically developed for use in neurodegenerative disease models such as Alzheimer’s, Huntington’s, and ALS, which affect millions globally.

Benefits to using axoCells for neurodegenerative disease drug discovery

• Fuel robust in vitro models
• Designed specifically for neurodegenerative disease modelling
• Functional performance verified across multiple assay types
• axoCells characterised for phenotypic relevance
• Avoid ethical concern
   

Select your axoCell type 

• Neurons: Including coritcal excitatory neurones, coritcal inhibitory neurones, striatal neurones, motor neurones and sensory neurones
• Inflammatory cells: Including microglia and astrocytes
• Muscle cells: Myotubes

The functional performance of all axoCells are evaluated using various assays, including electrophysiology (MEA), calcium imaging (SNA), and neurite outgrowth, ensuring your research produces the most accurate results.

Fuel advanced in vitro ALS models with axoCells motor neurones

AXOL extensively characterise axoCells for phenotypic relevance including morphology and key cell markers

Figure 1: Left: Phase contrast images of control axoCells motor neurons matured from progenitors over 21 days. Right: Immunocytochemistry of day 21 mature axoCells motor neurons showing key marker presence (ChAT and TUJ1).

Boost your amyotrophic lateral sclerosis research further with AXOL's ALS toolbox

The toolbox features motor neurons from six distinct donor lines: two unaffected donors, one donor carrying the C9orf72 mutation (a sibling of an ALS donor), and three donors each with key ALS-associated genotypes - SOD1, C9orf72, and TDP43.

Downloadable materials
ALS tools brochure
Alzheimer's tools brochure