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Researchers developing antibody-based studies often face challenges that off-the-shelf products cannot solve, from the need for engineered antibody formats to requirements for consistent supply at larger scales. As the original manufacturer of its antibodies, Bio X Cell offers a comprehensive portfolio of custom services designed to deliver high-quality, in vivo-ready antibodies tailored to specific research goals. With expertise spanning antibody engineering, production, formulation, quality control, and conjugation, Bio X Cell helps researchers obtain the exact materials needed to advance preclinical and translational studies with confidence.
Why choose Bio X Cell for custom antibody services?
- Original manufacturer with end-to-end control of expression, purification, formulation, and quality control.
- In vivo-ready quality standards, including high purity, low endotoxin levels, and additive-free formulations.
- Support for projects ranging from milligram to gram-scale production.
- Scientific partnership from antibody design through production and characterisation.
- Flexible customisation options including engineering, formulation adjustments, quality testing, and conjugation services.
- Consistent supply and continuity to support long-term and multi-study research programmes.
Catalogue customisation options
Bio X Cell’s catalogue customisation services enable researchers to adapt proven catalogue antibodies to the specific requirements of their study. By tailoring product preparation, quality attributes, and supporting analytical services, researchers can streamline workflows, meet project-specific specifications, and accelerate study initiation.
Available customisation options include:
- Lower endotoxin level preparation for sensitive research applications
- Custom concentration and buffer adjustments to match experimental requirements
- Custom vialing configurations to support workflow and dosing needs
- Optional aggregation analysis to assess product quality and stability
- Binding validation services to confirm antibody performance
- Murine pathogen testing for studies requiring additional biological screening
Scalable antibody production from existing hybridoma or cell line
For researchers with an established hybridoma or stable cell line, Bio X Cell provides a streamlined pathway to high-quality antibody production at scales ranging from milligrams to grams. The service is designed to deliver purified antibodies using low-endotoxin processes while maintaining the consistency and quality required for demanding research programs.
Key features include:
- Production starting from existing hybridoma or stable HEK/CHO cell lines
- Flexible scale-up from milligram to gram quantities
- Protein A/G purification and buffer exchange as part of the manufacturing workflow
- Low-endotoxin production processes to support sensitive applications
- Delivery of purified antibody accompanied by a Certificate of Analysis (CoA)
- Access to ultra-low endotoxin antibody production capabilities for research-use-only applications
Fast recombinant antibody production from DNA or sequence
Bio X Cell offers rapid recombinant antibody production starting from either antibody sequence information or plasmid DNA. Combining antibody engineering expertise with scalable expression and purification capabilities, the service supports the creation of customised recombinant antibodies with in vivo-ready quality.
Service capabilities include:
- Project initiation from antibody variable region sequences or plasmid DNA
- Comprehensive engineering support, including species switching, Fc modifications, tags, antibody fragments, and bispecific formats
- Production scales ranging from 100 mL to 20 L
- Protein A/G purification with optional additional polishing steps
- Delivery of purified antibody with a Certificate of Analysis (CoA)
- End-to-end support from sequence through to purified recombinant antibody
Custom conjugation services
Bio X Cell’s custom conjugation services leverage high-purity, preservative-free antibodies to simplify conjugation workflows and support consistent performance in preclinical and imaging studies. By combining antibody production and conjugation under one provider, researchers can reduce transfer risks and maintain continuity throughout their project.
Conjugation service options include:
- Direct use of Bio X Cell antibodies without the need for buffer exchange
- Conjugation to fluorophores, biotin, in vivo imaging dyes, and select linker or oligonucleotide chemistries
- In vivo-compatible formulations designed to preserve antibody function without azide or disruptive additives
- Defined quality control assessments, including fluorophore-to-protein ratio and concentration testing
- Optional endotoxin analysis, HPLC, and mass spectrometry testing
- Single-vendor management of both antibody production and conjugation for greater consistency and workflow continuity