£283.00
Estimated delivery Wed 29 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
53126-63-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
544.6
Alternative Names:
6,8a,11a,12,21,22-hexahydro-23-hydroxy-19-(1-hydroxyethyl)-7,11a-dimethyl-spiro[10,12:19,22a-dimethano-4h,5h,22ah-oxireno[8,9][1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-11(10h),2′-oxirane]-2,14(1ah,19h)-dione
- Data sheet: View or download
- MSDS: View or download
Product Description:
A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml); intranasal administration induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice at 500 µg/kg; induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.)
Storage Temperature:
-20°C
