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ELISA, IF Microscopy, Western Blot
Rabbit
H. sapiens (Human)
IgG
Polyclonal
Anti-ADAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the N-term
ADAP Antibody, ADAP, PRO0823, SLAP-130, SLAP130, FYN-binding protein, Adhesion and degranulation promoting adaptor protein, FYB-120/130, p120/p130, FYN-T-binding protein, SLP-76-associated phosphoprotein
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x (L) , suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist. Anti-ADAP Antibody has been tested for use in ELISA, Immunocytochemistry, Immunofluorescence and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 119 kDa in Western Blots of specific cell lysates and tissues.
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended sto
