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Anti-NFkB p65 Rabbit Monoclonal Antibody

Supplier:
Catalogue number:
A1591-50
Size:
50 µl
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£364.00 Estimated delivery Wed 21 Apr
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NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

Rabbit IgG

Formulation:

In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Antibody Type:

Monoclonal

Clone Number:

RM273

UNSPSC Code:

12352203

Anti-NFkB p65 Rabbit Monoclonal Antibody

Anti-NFkB p65 Rabbit Monoclonal Antibody