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Anti-Phospho-ERK1/2 (Thr202/Tyr204) Antibody

Supplier:
Catalogue number:
A1589-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£505.00 Estimated delivery Wed 28 Apr
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localised in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.

Product Type:

Antibodies

Species Reactivity:

Human, Mouse, Rat

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

Rabbit IgG

Formulation:

In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Antibody Type:

Polyclonal

UNSPSC Code:

12352203

Anti-Phospho-ERK1/2 (Thr202/Tyr204) Anti

Anti-Phospho-ERK1/2 (Thr202/Tyr204) Antibody