£411.00
Estimated delivery Fri 24 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
193275-84-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
638.8
Alternative Names:
4-[2-[4-[(11r)-3,10-dibromo-8-chloro-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, sarasar, sch 66336
- Data sheet: View or download
- MSDS: View or download
Product Description:
A farnesyltransferase inhibitor that blocks the post-translational lipid modification of oncogenic Ras isoforms H-Ras, N-Ras, and K-Ras (IC50s = 1.9, 2.8, and 5.2 nM, respectively) and Rheb (IC50 = 10-100 nM); demonstrates potent dose-dependent oral activity in an array of human tumor xenograft models including tumors originating from colon, lung, pancreas, prostate, and urinary bladder
Storage Temperature:
-20°C
