Human PD-L1 inhibitor IV
Catalogue number:
ANA65584
Supplier:
Size:
1 mg _$$_
Product is available in:
£355.00
Estimated delivery Thu 23 May
Shipping is calculated in checkout
Shipping is calculated in checkout
Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
1857
Product Description:
Programed cell death 1 (PD-1) receptor and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells were identified to overexpress PD-L1 so as to escape from the PD-1/PD-L1 immunosurveillance mechanism. This peptide, hPDL-1 inhibitor IV binds to human PD-1 and inhibits PD-1/PD-L1 binding. It has anchor residues (underlined), GNWDYNSQRAQLYNQ that show a great impact on the binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway became popular approach to cancer treatment.
Storage Temperature:
-20°C