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124858-35-1
≥98%
A crystalline solid
360.4
9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1h,5h-benzo[ij]quinolizine-2-carboxylic acid, opc 7251
- Data sheet: View or download
- MSDS: View or download
A fluoroquinolone antibiotic; active against clinical isolates of S. aureus, coagulase-negative staphylococci, P. acnes, and P. granulosum (MIC50s = 0.03, 0.06, 0.25, and 0.125 mg/L, respectively); inhibits the activities of DNA gyrase and topoisomerase IV (IC50s = 8.83 and 3.22 mg/L, respectively, for the S. aureus enzymes); inhibits P. acnes-induced increases in the production of IFN-γ, IL-1β, and IL-12p70 in human PBMCs, as well as reduces P. acnes-induced increases in the production of IL-8 and IL-6 in isolated human keratinocytes; reduces the number of skin lesion CFUs in a mouse model of burn wounds infected with S. aureus or P. acnes when applied topically as a cream at 1%
-20°C
