£374.00
Estimated delivery Tue 7 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
116313-94-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
265.2
Alternative Names:
3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione, or-462
- Data sheet: View or download
- MSDS: View or download
Product Description:
An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and brain S-COMT (ID50s = 5, 5, and 25 mg/kg, respectively); reduces 3-OMD formation and increases serum and brain L-DOPA, dopamine, and DOPAC levels when administered in combination with L-DOPA and carbidopa from 3-30 mg/kg; reduces mechanical and cold allodynia in a rat model of spinal nerve ligation-induced neuropathy at 30 mg/kg
Storage Temperature:
-20°C
