£303.00
Estimated delivery Fri 10 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
65974-52-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
265.2
Alternative Names:
2-[(2-nitrophenyl)methylene]-propanedioic acid, 1,3-dimethyl ester, nsc 126224
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TLR4 antagonist; selectively inhibits NO production induced by LPS (IC50 = 0.31 µM) over the R-848, Pam3CSK4, and poly(I:C) in RAW 264.7 macrophages but also inhibits NO production induced by FSL-1 in the same cells at 0.6 µM; inhibits LPS-induced NF-κB activity in a reporter assay using BV-2 microglial cells and LPS-induced increases in IL-1β and TNF-α levels in RAW 264.7 macrophages (IC50s = 5.92, 0.42, and 1.54 µM, respectively)
Storage Temperature:
-20°C