Cycloguanil (hydrochloride)
Catalogue number:
CAY16861-50 mg
Supplier:
Size:
50 mg _$$_
Product is available in:
£181.00
Estimated delivery Wed 8 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
152-53-4
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
288.2
Alternative Names:
1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine, monohydrochloride, chloroguanide triazine, nsc 3074
- Data sheet: View or download
- MSDS: View or download
Product Description:
The active metabolite of proguanil; formed from proguanil by CYP2C19 and CYP3A in human liver microsomes; an inhibitor of DHFR (Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively); active against ten P. falciparum field isolates (IC50s = 0.12-1,400 µg/ml); reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg); reduces parasitemia in a rhesus monkey model of P. cynomolgi infection at 0.3 mg/kg
Storage Temperature:
-20°C
