[Trp63, 64]-C3a (63-77)

This peptide, which is a C-terminal analogue of the complement factor C3a, acts as an agonist to the C3a receptor. It is derived from the fifteen C-terminal residues (6-77) of C3a. In in vitro studies, both C 3a and this peptide have been shown to selectively bind to C3aRs and induce degranulation of C3aR-transfeted RBL-2H3 cells. There was also a rapid, transient and concentration-dependent hypertensive response observed in rats when infused intravenously with C3a and this peptide.