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[Pyr3]-beta-Amyloid (3-40), Human

Supplier:
Catalogue number:
ANA29906-1
Size:
1 mg
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This peptide triggers the formation of insoluble Aβ peptide deposits, inhibits secretion of amyloid protein precursor (APP) and increases cell-associated APP. The fibrils in the plaques formed in the brains of patients with Alzheimer’s disease contain significant amounts of truncated Aβ proteins such as Aβ(3-40) and Aβ (11- 40). These two fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

4125.7

Reference:

Ref: Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000); Russo, C. et al. Nature. 405, 531 (2000).

UNSPSC Code:

12352202

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