Like neuropeptide Y (NPY) and other peptides of the family, this peptide adopts a folded hairpin structure with the terminal segments in close proximity. An intracerebroventricular injection of NPY or [Leu31, Pro34]-NPY (non-Y2 receptor agonist) given during middle cerebral artery occlusion increases the infarct volume and nitric oxide (NO) overproduction in the rat brain.
Proteins & Peptides
Peak Area by HPLC ≥95%
Ref: Futilendorf, I. et al. Proc. Natl. Acad. Sci. USA 87, 182 (1990). Khiat, AJ. Pept. Res. 51, 317 (1998); Chen, S. and RJ. Cheung, Biomed. Sci.12, 267 (2005); Chen, S. and RJ. Cheung, Biomed. Sci. 11, 781 (2004); Labelle, M. et al. Peptides 18, 801 (1997)