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Brevetoxin 2

Supplier:
Catalogue number:
b6917-5 mg
Size:
5 mg
Product is available in:
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£10612.00 Estimated delivery Tue 28 Sep
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Polyether neurotoxin found in Karenia brevis; Nav1.4/1.5 Na+ channel activator.

Product Type:

Biochemicals

CAS Number:

79580-28-2

Alternative Names:

PbTx-2

Storage Temp:

-20°C

Compound Purity:

≥95%

Molecular Weight:

895.2

Reference:

Zaias J, Fleming LE, Baden DG, et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep. Inhal Toxicol. 2011 Mar;23(4):205-11. PMID: 21456953. Liberona JL, Cárdenas JC, Reyes R, et al. Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes. Cell Calcium. 2008 Sep;44(3):289-97. PMID: 18276006. Radwan FF, Ramsdell JS. Brevetoxin forms covalent DNA adducts in rat lung following intratracheal exposure. Environ Health Perspect. 2008 Jul;116(7):930-6. PMID: 18629316. Cao Z, George J, Baden DG, et al. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways. Brain Res. 2007 Dec 12;1184:17-27. PMID: 17963734. Bottein Dechraoui MY, Ramsdell JS. Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels. Toxicon. 2003 Jun;41(7):919-27. PMID: 12782093. Berman FW, Murray TF. Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons. J Pharmacol Exp Ther. 1999 Jul;290(1):439-44. PMID: 10381810.

Structure:

C50H70O14

Formula:

C50H70O14

UNSPSC Code:

12352200

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