C1s/C1-INH, Human, ELISA

Investigate and unravel early complement activation in complement-mediated diseasesComplement-mediated inflammation is linked to a wide variety of diseases. In some cases, it is important to intervene as early as possible in this process as it has direct clinical implications. Currently C1-INH administration in its natural or recombinant form is an approved treatment for hereditary angioedema (HAE).C1-INH or other early complement inhibitors are investigated for better targeted therapies in pending clinical studies. Hence the C1-INH complexes can be used as an indirect marker for ongoing classical or lectin pathway activation.Why looking at C1-INH and its complexes?C1-INH administration is an approved common treatment for hereditary angioedema (HAE) and in clinical trials for:- Covid-19 infections- Prevention of rejection in kidney transplantation- Traumatic brain injury and acute ischemic stroke- Endotoxemia, sepsis, inflammation and multiple organ failure- Application in end stage renal disease and chronic kidney diseaseThe key advantages:- Ready-to-use ELISA’s with a working time of 1 hour and 45 minutes- Acute and reliable quantification of C1s/C1-INH complex- Uses EDTA-plasma as input sample. No need for complement-preserved serum to assess early lectin pathway activation- First on the market available ELISA assay to measure early classical and early lectin pathway activation

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