This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1562338-42-4
Purity:
99.78
Molecular Weight:
393.48
Alternative Names:
LMI070; NVS-SM1
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 µM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)