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PF-06873600

Catalogue number:
CAY35502-5 mg
Supplier:
Size:
5 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£369.00 Estimated delivery Wed 1 May
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2185857-97-8

Purity:

≥98%

Formulation:

A solid

Molecular Weight:

471.5

Alternative Names:

6-(difluoromethyl)-8-[(1r,2r)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-pyrido[2,3-d]pyrimidin-7(8h)-one, pf-3600

Product Description:

An inhibitor of Cdk2, Cdk4, and Cdk6 (Kis = 0.13, 1.25, and 0.11 nM, respectively); selective for these CDKs over Cdk1 and Cdk9 (Kis = 4.5 and 19.6 nM, respectively); inhibits the phosphorylation of RB1 in, and the proliferation of, OVCAR-3 ovarian cancer cells (EC50s = 19 and 45 nM, respectively); reduces tumor volume in CTG-0464 and CTG-01912 NSCLC PDX mouse models at 30 mg/kg

Storage Temperature:

-20°C

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