PF-06873600
Catalogue number:
CAY35502-5 mg
Supplier:
Size:
5 mg
Product is available in:
£369.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2185857-97-8
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
471.5
Alternative Names:
6-(difluoromethyl)-8-[(1r,2r)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-pyrido[2,3-d]pyrimidin-7(8h)-one, pf-3600
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of Cdk2, Cdk4, and Cdk6 (Kis = 0.13, 1.25, and 0.11 nM, respectively); selective for these CDKs over Cdk1 and Cdk9 (Kis = 4.5 and 19.6 nM, respectively); inhibits the phosphorylation of RB1 in, and the proliferation of, OVCAR-3 ovarian cancer cells (EC50s = 19 and 45 nM, respectively); reduces tumor volume in CTG-0464 and CTG-01912 NSCLC PDX mouse models at 30 mg/kg
Storage Temperature:
-20°C