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ATN-161 (trifluoroacetate salt)

Catalogue number:
CAY34056-1 mg
Supplier:
Size:
1 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£42.00 Estimated delivery Fri 3 May
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

904763-27-5

Purity:

≥95%

Formulation:

A crystalline solid

Molecular Weight:

711.7

Alternative Names:

1-acetyl-l-prolyl-l-histidyl-l-seryl-l-cysteinyl-l-aspartamide, monotrifluoroacetate salt, ac-phscn-nh2, phscn peptide

Product Description:

An integrin receptor antagonist; binds to αVβ3 and αVβ5 receptors (Kds = 0.69 and 1 µM, respectively) in MDA-MB-231 cells; inhibits the interaction between αVβ5 and human ACE2 or SARS-CoV-2 spike protein in cell-free assays; reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 = 3.16 µM); inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells at 0.1 µM; reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model at 1 mg/kg; reduces infarct volume and edema in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg

Storage Temperature:

-20°C

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