£126.00
Estimated delivery Tue 7 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
448906-42-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
286.3
Alternative Names:
2-(1h-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester
- Data sheet: View or download
- MSDS: View or download
Product Description:
An endogenous AhR agonist; binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays at 0.01 µM; inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells at 1 µM; reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by CFA and M. tuberculosis at 200 µg/animal; reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model at 80 mg/kg
Storage Temperature:
-20°C