£328.00
Estimated delivery Tue 30 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
448906-42-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
286.3
Alternative Names:
2-(1h-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester
- Data sheet: View or download
- MSDS: View or download
Product Description:
An endogenous AhR agonist; binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays at 0.01 µM; inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells at 1 µM; reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by CFA and M. tuberculosis at 200 µg/animal; reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model at 80 mg/kg
Storage Temperature:
-20°C