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Arenobufagin

Supplier:
Catalogue number:
CAY30695-5 mg
Size:
5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£169.00 Estimated delivery Tue 22 Jun
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A cardiotonic steroid with anticancer activity; inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes (IC50 = 290 nM); increases cleavage of PARP, caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells; It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively); reduces tumor growth, the number and size of lung metastases, and tumor levels of the EMT markers vimentin and β-catenin in a PC3 mouse xenograft model at 1 mg/kg; inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice at 5 and 10 µM/plug

Product Type:

Biochemicals

CAS Number:

464-74-4

Alternative Names:

(3β,5β,11α)-3,11,14-trihydroxy-12-oxo-bufa-20,22-dienolide

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥95%

UNSPSC Code:

12352200

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