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ACHP

Supplier:
Catalogue number:
CAY14504-5 mg
Size:
5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£241.00 Estimated delivery Fri 18 Jun
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An inhibitor of IKKβ and IKKα (IC50s = 8.5 and 250 nM, respectively); selective for IKKβ and IKKα over IKKγ, Syk, and MKK4 (IC50s = >20 µM for all); reduces the constitutive phosphorylation of IκBα and NF-κB p65 in U266 and NCU-MM-2 cells at 50 µM; prevents TNF-α-induced activation of NF-κB in U266 cells at 0.1 µM; inhibits the growth of U266, NCU-MM-2, ILKM2, and BJAB cells (IC50s = 18.3, 27.6, 34.6, and 17.6 µM, respectively); prevents TNF-α-induced HIV-1 replication in latently HIV-1-infected OM10.1 cells (EC50 = 0.56 µM); prevents PMA-and imiquimod-induced skin inflammation in mice at 5 mg/kg

Product Type:

Biochemicals

CAS Number:

406208-42-2

Alternative Names:

2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

Storage Temp:

-20°C

Formulation:

A solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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