Cambridge Bioscience offers both adenoviral and lentiviral based gene delivery vectors for high efficiency delivery of DNA via viral transduction methods. In addition, we provide producer and packaging cell lines along with the reagents to concentrate, purify and quantify viral particles and monitor levels of replication competency.
Selection guide for recombinant viruses for gene delivery
| Adenovirus | AAV | Lentivirus | Retrovirus | |
|---|---|---|---|---|
| Gene expression | Transient | Transient or stable | Transient or stable | Stable |
| Infect dividing cells | Yes | Yes | Yes | Yes |
| Infect non-dividing cells | Yes | Yes | Yes | No |
| Integration into target cell genome | No | No* | Yes | Yes |
| Immune response in target cells | High | Very low | Low | Moderate |
| Relative viral titre | ++++ | +++ | +++ | ++ |
| Relative transduction efficiency | ++++ | +++ | +++ | ++ |
*Native AAV will integrate but recombinant AAV rarely does
