Remdesivir

Several clinical studies have highlighted the potential role of remdesivir (GS-5734), as an effective SARS-CoV-2 antiviral drug. Studies examining the pharmacological and human safety profile of remdesivir will enable the preclinical and clinical evaluation of these drugs for the treatment of COVID-19.

Cambridge Bioscience offers a wide range of sizes of high purity remdesivir with short lead-times from our partners Cayman Chemical, MedChemExpress and Biovision.

Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity.

Remdesivir references
Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.

Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

Riva, L., Yuan, S., Yin, X. et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature (2020).

Thi Nhu Thao T, Labroussaa F, Ebert N, et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020;582(7813):561-565. doi:10.1038/s41586-020-2294-9

Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells [published online ahead of print, 2020 Aug 7]. J Med Virol. 2020;10.1002/jmv.26397.

Yin W, Mao C, Luan X, et al. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020;368(6498):1499-1504.

Yuan S, Chan CC, Chik KK, et al. Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19). Viruses. 2020;12(6):628. Published 2020 Jun 10

Parang K, El-Sayed NS, Kazeminy AJ, Tiwari RK. Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs Against Human Coronavirus 229E (HCoV-229E). Molecules. 2020;25(10):2343. Published 2020 May 17

Please note that these products are for in vitro laboratory research use only and are not suitable for human consumption or veterinary diagnostic or therapeutic use.