£142.00
Estimated delivery Wed 29 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
122320-73-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
357.4
Alternative Names:
5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, brl 49653
- Data sheet: View or download
- MSDS: View or download
Product Description:
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Storage Temperature:
-20°C
