£87.00
Estimated delivery Wed 8 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
162054-19-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
384.3
Alternative Names:
5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1h-pyrazole
- Data sheet: View or download
- MSDS: View or download
Product Description:
SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 value of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465}
Storage Temperature:
-20°C
