Thioetheramide-PC
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116457-99-9
≥95%
A solution in ethanol
735.1
1,2-dideoxy-1-(s-hexadecyl)thio-2-(n-hexadecanoyl)amino-sn-glyceryl-3-phosphorylcholine, 1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
- Data sheet: View or download
- MSDS: View or download
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2.{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
-20°C
