£462.00
Estimated delivery Fri 10 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2412902-55-5
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
591.7
Alternative Names:
benzyl (3-(5-carbamoyl-2-(1-ethyl-3-methyl-1h-pyrazole-5-carboxamido)-7-(3-methoxypropoxy)-1h-benzo[d]imidazol-1-yl)propyl)carbamate
- Data sheet: View or download
- MSDS: View or download
Product Description:
A STING agonist (IC50 = 0.3794 µM in a competition binding assay); activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay); activates the STING-TBK1-IRF3 signaling pathway; increases the secretion of IFN-β and the levels of CXCL10 and IL-6 in PBMCs at 10 µM; reduces tumor growth in a CT26 murine colon cancer model at 0.15, but not 1.5, mg/kg
Storage Temperature:
-20°C
