27-Hydroxycholesterol
Catalogue number:
B2988-5
Supplier:
BioVision
Size:
5 mg _$$_
Product is available in:
N/A
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CAS Number:
20380-11-4
Purity:
0.98
Molecular Weight:
402
Alternative Names:
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (25R)-26-hydroxy Cholesterol; (3β,25R)-Cholest-5-ene-3,26-diol; 25(R)-27-hydroxy Cholesterol
- Data sheet: View or download
- MSDS: View or download
Product Description:
27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis. The levels of 27-hydroxycholesterol are elevated in patients with Alzheimer's disease and mild cognitive impairment.
Storage Temperature:
-20°C
