15-keto Prostaglandin E2
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26441-05-4
≥98%
A crystalline solid
350.5
9,15-dioxo-11α-hydroxy-prosta-5z,13e-dien-1-oic acid, 15-keto pge2, 15-oxo pge2
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- MSDS: View or download
A metabolite of PGE2; does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively) but does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells; inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells; reduces mortality in a mouse model of LPS-induced sepsis at 15 mg/kg
-20°C