Prostaglandin E2-1-glyceryl ester
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37497-47-5
≥98% (as a 85:15 mixture of the 1- and 2-glyceryl
A solution in ethanol
426.6
9-oxo-11α,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, 1-glyceryl ester, pge2-1-glyceryl ester
- Data sheet: View or download
- MSDS: View or download
2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{4614,5306} Incubation of 2-AG with COX-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}
-80°C
