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Human CellExp™ Siglec-15, Human Recombinant

Supplier:
Catalogue number:
P1343-50
Size:
50 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£428.00 Estimated delivery Wed 28 Apr
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Siglec-15 is a transmembrane glycoprotein of the siglecs family that participates in the immune regulatory systems through the recognition of their glycan ligands. Siglecs, short for sialic acid-binding immunoglobulin (Ig)-like lectins, are primarily expressed on the surface of immune cells and differentially control innate and adaptive immune responses. Mature human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD, Phe20 - Thr263) with two Ig-like domains, a 21 aa transmembrane segment (264-284), and a 44 aa cytoplasmic domain (285-328). Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemia, and ability to modulate receptor signaling. Because Siglec-15 is critical for proper development and function of osteoclasts, anti-Siglec-15 antibodies have therapeutic potential for treatment of osteoporosis.

Product Type:

Proteins and peptides

Alternative Names:

Sialic acid-binding immunoglobulin (Ig)-like lectin 15, CD33 antigen-like 3, CD33 molecule-like 3, CD33L3

Storage Temp:

-20°C

Molecular Weight:

27

UNSPSC Code:

12352202

Human CellExp™ Siglec-15, Human Recombin

Human CellExp™ Siglec-15, Human Recombinant